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Odessa is centrally located in east-central Washington, at the crosswords of State Highways 28 and 21, and is just 18 miles north of Interstate 90, at the Highway 21 exit #206.
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Mileage from major cities in Washington are Seattle and Puget Sound area, 200 miles; Spokane 75 miles; Yakima 140 miles; Wenatchee 100 miles; Tri-Cities 100 miles, Walla Walla 110 miles and Pullman 110 miles.